HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Aminopyrrole → 2-chloro-5-fluoro-N-(1H-pyrrol-1-yl)-4-pyrimidineamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Aminopyrrole | HCID 136589 | — |
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Product | 2-chloro-5-fluoro-N-(1H-pyrrol-1-yl)-4-pyrimidineamine | HCID 22060431 | — |
Reaction Steps
In like manner to the preparation of 2-chloro-N-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine was reacted with 1-aminopyrrole to produce 2-chloro-5-fluoro-N-(1H-pyrrol-1-yl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 11.39 (s, 1H), 8.35 (d, 1H, J=3.5 Hz), 6.83 (t, 2H, J=2.3 Hz), 6.07 (t, 2H, J=2.3 Hz). LCMS: ret. time: 18.95 min.; purity: 97%; MS (m/e): 213 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822685B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-fa5e40a8987544ff9eb9bf59a97a40fc |
| Source note | uspto-grants-2014_09 |