Hydrochloric Acid → 5-Fluorospiro[indene-2,4'-piperidin]-1(3H)-one

Participants

Reaction Steps

To a stirred solution of ethyl 5-fluoro-1-oxo-1,3-dihydrospiro[indene-2,4′-piperidine]-1′-carboxylate (188 mg, 0.645 mmol) in HCl (19.61 μL, 0.645 mmol) was heated at 100° C. over night. The reaction mixture was concentrated to dryness without any further purification to give the title compound (160 mg, 97% yield). MS calculated for C13H15FNO 220.3. found (ESI) m/z 220.0 (M+H)+, retention time 0.51 min.

Provenance & Evidence