Trifluoroacetic acid → (2,3-dihydro-5-benzofuranyl)-4-piperidinylMethanone

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Reaction Steps

To a solution of 4-(2,3-dihydro-benzofuran-5-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester (0.50 g, 1.5 mmol) in 10 mL of DCM, was added 1 mL of TFA. The reaction mixture was stirred at ambient temperature for 2.5 hours then the solvent was removed by reduced pressure to yield the title product (0.3 g, 1.3 mmol). MS (ESI) m/z 232.3 (M+H+); HPLC (Novapak 150×3.9 mm C-18 column: mobile phase: 35-90% acetonitrile/water with 0.1% TFA, at 2 mL/min over 2 min.) t 1.14 min.

Provenance & Evidence