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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 713464Generated: October 31, 2026

Trifluoroacetic acid → HCID 20613884, compound

https://huagongshe.com/reaction/713464

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 71227085HCID 71227085—
SolventDichloromethaneHCID 6344—
ProductHCID 20613884HCID 20613884100.3%

Reaction Steps

The a solution of 4-(4-benzyloxy-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (313 mg, 0.79 mmol) in dichloromethane (10 mL) was added TFA (0.61 mL, 7.9 mmol). The reaction was stirred for 3 hours and then the solvent removed under vacuum and placed under high vacuum to afford the title compound (234 mg). LRMS m/z: ES+=295.9 (M+H), retention time 1.18.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181266B2
Source datasetuspto-grants-2015_11
ORD IDord-9d498433286d4e608a3277a54224f9a6
Source noteuspto-grants-2015_11