2-(4-(4-Methoxybenzoyl)piperidin-1-YL)acetic acid → 2-(4-(4-Methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,6,7,8,9-hexahydro-3H-cyclohepta[d]pyrimidin-2-yl)methyl)acetamide

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Reaction Steps

The title compound (89 mg, 44% yield) was prepared following the general procedure of Example 1 from 2-(4-(4-methoxybenzoyl)piperidin-1-yl)acetic acid (124 mg, 0.45 mmol) and 2-(aminomethyl)-6,7,8,9-tetrahydro-3H-cyclohepta[d]pyrimidin-4(5H)-one (87 mg, 0.45 mmol). 1H NMR (400 MHz, CDC3) δ 11.36 (br. s., 1H), 8.01 (br. s., 1H), 7.83-7.89 (m, J=9.1 Hz, 2H), 6.85-6.91 (m, 2H), 4.30 (d, J=5.6 Hz, 2H), 3.81 (s, 3H), 3.12-3.29 (m, 1H), 2.97-3.12 (m, 2H), 2.92 (br. s., 2H), 2.55-2.83 (m, 4H), 2.30 (br. s., 2H), 1.67-1.94 (m, 6H), 1.40-1.67 (m, 4H). HRMS calculated for C23H32N4O4 453.2502. found (ESI, [M+H]+), 453.2509. Retention time=3.09.

Provenance & Evidence