2-(4-(4-Methoxybenzoyl)piperidin-1-YL)acetic acid → HCID 136237333, compound

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Reaction Steps

The title compound (70 mg) was prepared following the general procedure of Example 1 from 2-(4-(4-methoxybenzoyl)piperidin-1-yl)acetic acid (307 mg, 0.78 mmol, 70% purity) and 2-(aminomethyl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one (128 mg, 0.78 mmol). 1H NMR (400 MHz, CDC3) δ 10.58 (br. s., 1H), 8.06 (br. s., 1H), 7.95 (d, J=9.1 Hz, 2H), 6.98 (d, J=9.1 Hz, 2H), 4.41 (d, J=6.1 Hz, 2H), 3.90 (s, 3H), 3.28 (br. s., 3H), 3.02 (br. s., 2H), 2.70-2.95 (m, 4H), 2.43 (br. s., 2H), 2.09 (dq, J=7.8, 7.7 Hz, 2H), 1.91 (br. s., 4H). HRMS calculated for C23H28N4O4 425.2189. found (ESI, [M+H]+), 425.2180. Retention time=4.65 min.

Provenance & Evidence