2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → N-Cyclopropylmethyl-2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-N-(4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-ylmethyl)-acetamide

Participants

Reaction Steps

Following the general procedure of Example 4, the title compound was prepared (14.4 mg) from 2-[(Cyclopropylmethyl-amino)-methyl]-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C26H31FN4O4 482.55. found 483.3 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.98 (dd, J=8.59, 5.56 Hz, 2H) 7.19 (t, J=8.59 Hz, 2H) 4.65 (s, 1H) 4.58 (br. s., 1H) 4.41-4.55 (m, 2H) 4.26 (br. s., 1H) 4.18 (br. s., 2H) 3.85-3.98 (m, 3H) 3.30 (d, J=7.07 Hz, 1H) 3.22 (d, J=6.57 Hz, 2H) 2.70 (br. s., 1H) 2.64 (br. s., 1H) 2.22 (br. s., 4H) 0.97 (d, J=4.55 Hz, 1H) 0.61 (d, J=7.58 Hz, 1H) 0.42 (d, J=7.07 Hz, 1H) 0.26 (d, J=4.55 Hz, 1H) 0.13-0.22 (m, 1H).

Provenance & Evidence