2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237371, compound

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Reaction Steps

Following the general procedure of Example 4, the title compound was prepared (38.2 mg) from (S)-2-((2-methylbutylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C27H35FN4O4 498.6. found 499.7 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.88-8.15 (m, 2H) 7.20 (t, J=8.59 Hz, 2H) 4.44-4.68 (m, 4H) 4.09-4.25 (m, 1H) 3.85-3.99 (m, 2H) 3.80 (d, J=11.12 Hz, 2H) 3.42 (d, J=7.58 Hz, 2H) 3.22-3.36 (m, 2H) 3.17 (br. s., 1H) 2.66-2.76 (m, 1H) 2.20 (br. s., 3H) 1.26-1.47 (m, 1H) 1.06-1.25 (m, 1H) 0.93 (ddd, J=6.82, 3.79, 3.54 Hz, 4H) 0.78-0.90 (m, 2H).

Provenance & Evidence