2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237372, compound

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Reaction Steps

Following the general procedure of Example 4, the title compound was prepared (36.4 mg) from 2-((isobutylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C26H33FN4O4 484.6. found 485.6 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.98 (dd, J=8.84, 5.31 Hz, 2H) 7.20 (t, J=8.59 Hz, 2H) 4.48-4.67 (m, 4H) 4.21 (br. s., 2H) 3.89-4.01 (m, 2H) 3.82 (br. s., 3H) 3.23 (br. s., 4H) 2.62-2.83 (m, 2H) 2.19 (br. s., 3H) 2.13 (s, 1H) 2.07 (d, J=6.57 Hz, 1H) 0.98 (d, J=6.57 Hz, 4H) 0.88 (d, J=5.56 Hz, 2H).

Provenance & Evidence