2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237374, compound

Participants

Reaction Steps

Following the general procedure of Example 4, the title compound was prepared (20.2 mg) from (R)-2-(((tetrahydrofuran-2-yl)methylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C27H33FN4O4 512.6. found 513.7 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.89 (dd, J=8.84, 5.31 Hz, 2H) 7.11 (t, J=8.59 Hz, 2H) 4.52-4.69 (m, 1H) 4.28-4.52 (m, 4H) 4.09-4.28 (m, 3H) 3.77-3.95 (m, 5H) 3.62-3.74 (m, 2H) 3.28-3.45 (m, 4H) 2.54-2.62 (m, 1H) 2.19 (d, J=7.07 Hz, 1H) 2.12 (br. s., 3H) 1.84-2.02 (m, 4H).

Provenance & Evidence