2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237384, compound

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Reaction Steps

Following general procedure of Example 4, the title compound was prepared (11 mg) from (R)-2-((sec-butylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C26H33FN4O4 484.6. found 485.4 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.87-8.07 (m, 2H) 7.16 (t, J=8.59 Hz, 2H) 4.41-4.58 (m, 2H) 4.19-4.41 (m, 3H) 4.13 (d, J=7.07 Hz, 1H) 3.82-3.99 (m, 2H) 3.34 (br. s., 2H) 3.25 (br. s., 1H) 3.13 (br. s., 1H) 2.87-3.07 (m, 1H) 2.55-2.69 (m, 2H) 2.25 (br. s., 2H) 1.98 (br. s., 1H) 1.88 (br. s., 2H) 1.72 (br. s., 1H) 1.16-1.28 (m, 3H) 1.09 (d, J=6.57 Hz, 1H) 0.69-0.89 (m, 3H).

Provenance & Evidence