2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237385, compound

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Reaction Steps

Following general procedure of Example 4, the title compound was prepared (26.4 mg) from 2-((isopropylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C25H31FN4O4 470.5. found 471.6 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.91-8.18 (m, 2H) 7.19 (t, J=8.59 Hz, 2H) 4.53-4.69 (m, 2H) 4.50 (s, 1H) 4.24-4.43 (m, 1H) 4.19 (br. s., 1H) 3.86-4.08 (m, 3H) 3.80 (d, J=7.58 Hz, 1H) 3.58 (br. s., 2H) 3.33-3.50 (m, 1H) 3.28 (br. s., 1H) 2.74 (t, J=5.31 Hz, 2H) 2.19 (d, J=10.61 Hz, 2H) 2.13 (s, 1H) 1.11-1.33 (m, 5H) 1.07 (d, J=6.06 Hz, 1H).

Provenance & Evidence