2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136219321, compound

Participants

Reaction Steps

Following general procedure of Example 4, the title compound was prepared (37.3 mg) from 2-((propylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C25H31FN4O4 470.5. found 471.6 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.89-8.08 (m, 2H) 7.19 (t, J=8.34 Hz, 2H) 4.60 (s, 2H) 4.42-4.57 (m, 2H) 4.27 (br. s., 2H) 3.85-4.01 (m, 3H) 3.81 (br. s., 1H) 3.57 (br. s., 1H) 3.39 (br. s., 1H) 3.31 (br. s., 2H) 3.12-3.28 (m, 1H) 2.72 (br. s., 1H) 2.13 (s, 4H) 1.58-1.80 (m, 1H) 1.40-1.58 (m, 1H) 0.76-1.00 (m, 3H).

Provenance & Evidence