2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237395, compound

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Reaction Steps

Following general procedure of Example 4, the title compound was prepared (43.3 mg) from 2-((1-(2,4-difluorophenyl)ethylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C30H31F2N4O4 568.6. found 569.4 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.80-8.00 (m, 2H) 7.23-7.41 (m, 1H) 7.11 (t, J=8.59 Hz, 3H) 6.81-6.95 (m, 2H) 6.67-6.81 (m, 2H) 6.41-6.61 (m, 1H) 4.32-4.58 (m, 4H) 4.17-4.32 (m, 1H) 3.70-3.96 (m, 4H) 3.47 (d, J=11.12 Hz, 1H) 3.15-3.37 (m, 1H) 3.09 (br. s., 1H) 2.62 (br. s., 1H) 2.50 (br. s., 1H) 2.36 (br. s., 1H) 2.14 (br. s., 2H) 2.04 (s, 1H) 1.60 (d, J=6.57 Hz, 1H) 1.39 (d, J=6.57 Hz, 2H).

Provenance & Evidence