2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237396, compound

Participants

Reaction Steps

Following general procedure of Example 4, the title compound was prepared (17.7 mg) from 2-((benzylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. Exact mass calculated for C29H31FN4O4 518.58. found 519.4 (ESI, M+H); 1H NMR (400 MHz, dichloromethane-d2) δ ppm 7.98 (br. s., 2H) 7.28-7.52 (m, 1H) 7.21 (d, J=7.58 Hz, 4H) 4.66 (d, J=8.08 Hz, 2H) 4.60 (br. s., 1H) 4.48 (br. s., 2H) 3.85-4.08 (m, 5H) 3.81 (br. s., 2H) 3.42 (d, J=7.07 Hz, 2H) 3.28 (br. s., 2H) 2.70 (d, J=15.66 Hz, 2H) 2.06-2.36 (m, 3H) 1.17-1.41 (m, 2H)

Provenance & Evidence