Acetonitrile--water (1/1) → HCID 136237421, compound

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Reaction Steps

Following the general procedure of Example 1, the title compound was prepared (0.015 g) from 2-((2,2,2-trifluoroethylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid. 1H NMR (400 MHz, MeOD) δ ppm 8.04-8.18 (m, 2H), 7.21-7.33 (m, 2H), 4.62-4.70 (m, 2H), 4.36-4.53 (m, 5H), 4.17-4.30 (m, 1H), 3.87-4.00 (m, 2H), 3.66-3.80 (m, 2H), 3.38-3.59 (m, 1H), 3.08-3.26 (m, 2H), 2.54-2.69 (m, 2H), 1.93-2.27 (m, 4H). HRMS calculated for C24H27F4N4O4 511.1968. found (ESI, [M+H]+) 511.1963. MS (ESI) m/z 511.2. (M+H)+. Retention time: 3.02 min (5-95% CH3CN/H2O over 7.75 min with 0.1% formic acid, Inertsil ODS3 100×3 mm C18 column with flow rate of 1.0 mL/min).

Provenance & Evidence