HCID 71227054, compound → HCID 136627209, compound

Participants

Reaction Steps

The title compound (10 mg, 0.018 mmol) was prepared following the general procedure of Example 1 from {4-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-piperidin-1-yl}-acetic acid (100 mg, 0.246 mmol, 1.0 eq) and 2-aminomethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one (46.8 mg, 0.258 mmol, 1.05 eq). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.43 (br s, 1H) 8.27 (br s, 1H) 7.92 (d, J=9.03 Hz, 2H) 7.14 (d, J=9.03 Hz, 2H) 4.34 (s, 2H) 4.20 (d, J=5.52 Hz, 2H) 3.73-3.92 (m, 5H) 2.86-3.11 (m, 5H) 2.18-2.36 (m, 2H) 2.01-2.10 (m, 2H) 1.87-1.98 (m, 2H). HR-MS (m/z, MH+): 481.2205, 482.2262. HPLC retention time: 2.69 min (Agilent column 3.0×100 mm 3 um C18 column; flow rate of 1.0 mL/min with gradient from 5% to 95% acetonitrile in 10 min, 0.1% FA).

Provenance & Evidence