Acetonitrile--water (1/1) → HCID 136237472, compound

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Reaction Steps

The title compound (0.07 g) was prepared following the general procedure of Example 1 from 2-(4-benzoylpiperidin-1-yl)acetic acid and 2-((2,2-difluoroethylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one. 1H NMR (400 MHz, MeOD) δ ppm 7.89-8.03 (m, 2H), 7.44-7.66 (m, 3H), 5.88-6.43 (m, 1H), 4.61-4.69 (m, 1H), 4.53-4.60 (m, 1H), 4.40-4.48 (m, 1H), 3.78-4.23 (m, 5H), 3.36-3.59 (m, 2H), 3.02-3.18 (m, 1H), 2.83-2.93 (m, 1H), 2.54-2.69 (m, 3H), 2.13-2.36 (m, 2H), 1.65-1.97 (m, 3H), 1.37-1.54 (m, 1H). HRMS calculated for C24H29F2N4O4 475.2157. found (ESI, [M+H]+) 475.2180. MS (ESI) m/z 475.2. (M+H)+. Retention time: 3.04 min (5-95% CH3CN/H2O over 7.75 min with 0.1% formic acid, Inertsil ODS3 100×3 mm C18 column with flow rate of 1.0 mL/min).

Provenance & Evidence