Quinoline, 1,2,3,4-tetrahydro-6-methoxy- → HCID 136237298, compound

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Reaction Steps

The title compound (56 mg, 22% yield) was prepared following the general procedure of Example 1 from 1-(2-oxo-2-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methylamino)ethyl)piperidine-4-carboxylic acid (250 mg, 0.50 mmol) and 6-methoxy-1,2,3,4-tetrahydroquinoline (82 mg, 0.50 mmol). 1H NMR (400 MHz, CDC3) δ 10.68 (br. s., 1H), 8.12 (br. s, 0.5H), 6.97 (br. s., 0.5H), 6.73-6.80 (m, 2H), 4.58 (s, 2H), 4.38 (d, J=5.6 Hz, 2H), 3.97 (t, J=5.6 Hz, 2H), 3.63-3.89 (m, 5H), 3.10 (br. s., 2H), 2.89 (br. s., 3H), 2.71 (t, J=5.3 Hz, 4H), 2.15 (br. s., 2H), 1.82-2.09 (m, 5H), 1.68 (br. s., 1H). HRMS calculated for C26H33N5O5 496.2560. found (ESI, [M+H]+), 496.2561. Retention time=1.29 min.

Provenance & Evidence