2-(4-(4-Fluorobenzoyl)piperidin-1-YL)acetic acid → HCID 136237349, compound

Participants

Reaction Steps

The title compound (170 mg) was prepared according to the general procedure of Example 1 from 2-(1-(methylamino)ethyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one (320 mg, 1.5 mmol) and 2-(4-(4-fluorobenzoyl)piperidin-1-yl)acetic acid (450 mg, 1.7 mmol). 1H NMR (400 MHz, CDC3) δ 12.88 (br. s., 1H), 7.97 (dd, J=8.8, 5.3 Hz, 2H), 7.05-7.21 (m, 2H), 4.48-4.70 (m, 2H), 3.95 (t, J=5.5 Hz, 2H), 3.68 (d, J=12.5 Hz, 1H), 3.39 (br. s., 1H), 3.16-3.36 (m, 1H), 3.07-3.16 (m, 1H), 2.83-3.07 (m, 3H), 2.62-2.77 (m, 5H), 2.56 (t, J=9.8 Hz, 1H), 2.27-2.47 (m, 1H), 1.97-2.27 (m, 2H), 1.76-1.94 (m, 1H), 1.46-1.69 (m, 3H). HRMS calculated for C24H23FN4O4 457.2251. found (ESI, [M+H]+), 457.2257. Retention time=1.83 min.

Provenance & Evidence