HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 713635Generated: October 29, 2026
1-Hydroxybenzotriazole → HCID 118113275, compound
https://huagongshe.com/reaction/713635
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Amino-5-(trifluoromethyl)pyridine | HCID 735862 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid | HCID 2821908 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 118113275 | HCID 118113275 | 73.1% |
Reaction Steps
A mixture of 0.81 g of 2-amino-5-trifluoromethylpyridine, 1.13 g of 3-chloro-5-trifluoromethylpicolinic acid, 1.15 g of EDCI hydrochloride, 0.06 g of HOBt and 10 mL of pyridine was stirred at 60° C. for 2 hours. A saturated aqueous sodium bicarbonate solution was poured to the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting residue was applied to a silica gel column chromatography to obtain 1.35 g of 3-chloro-5-trifluoromethyl-N-(5-trifluoromethylpyridin-2-yl)picolinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09185910B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-415f64c56635417ebdc44d85f543ddd1 |
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| Source note | uspto-grants-2015_11 |
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