HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3,5-bis(trifluoromethyl)- → HCID 118113392, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3,5-bis(trifluoromethyl)- | HCID 9480 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-Chloropyridine-2-carboxylic acid | HCID 824632 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Catalyst | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 118113392 | HCID 118113392 | 91.5% |
Reaction Steps
A mixture of 1.15 g of 3,5-bistrifluoromethylaniline, 0.78 g of 3-chloropicolinic acid, 1.15 g of EDCI hydrochloride, 0.06 g of HOBt and 10 mL of pyridine was stirred at room temperature for 2 hours. A saturated aqueous sodium bicarbonate solution was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting solid was washed with hexane and dried to obtain 1.67 g of 3-chloro-N-(3,5-bistrifluoromethylphenyl)picolinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09185910B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-991fae8a76c54aa889c2f6e56a0f342c |
| Source note | uspto-grants-2015_11 |