Sulfuric Acid → 3-(Ethylsulfanyl)pyridine-2-carboxylic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 1.4 g of 3-ethylsulfanylpyridine-2-carbonitrile, 15 mL of concentrated sulfuric acid and 5 mL of water was stirred at 130° C. for 2 hours. Water was poured to the reaction mixture cooled to room temperature, sodium hydroxide was added thereto, and the mixture was extracted with ethyl acetate. Concentrated hydrochloric acid was added to the aqueous layer, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 1.15 g of 3-ethylsulfanylpicolinic acid.

Herkunft & Nachweise