Sodium Thiosulfate → HCID 118113312, compound

Participants

Reaction Steps

10.2 g of m-chloroperbenzoic acid (purity of 68%) was added to a mixture of 9.07 g of 5-chloro-3-ethylsulfanyl-N-methyl-N-(4-trifluoromethylsulfanylphenyl)picolinamide (Compound of Present Invention 158) and 223 ml of chloroform under ice cooling, and the mixture was stirred at room temperature for 5 hours. A saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium thiosulfate solution were poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting residue was applied to a silica gel column chromatography to obtain 7.0 g of 5-chloro-3-ethylsulfonyl-N-methyl-N-(4-trifluoromethylsulfanylphenyl)picolinamide (hereinafter, referred to as Compound of Present Invention 118) and 2.04 g of 5-chloro-3-ethylsulfonyl-N-methyl-N-(4-trifluoromethylsulfinylphenyl)picolinamide (hereinafter, referred to as Compound of Present Invention 117).

Provenance & Evidence