1,2-Dimethoxyethane → HCID 118113432, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 250 mg of 5-chloro-3-ethylsulfonyl-N-methyl-N-(4-trifluoromethylsulfanylphenyl)picolinamide (Compound of Present Invention 118), 104 mg of phenylboronic acid, 10 mg of tris(dibenzylideneacetone)dipalladium(0), 25 mg of 2-dicyclohexylphosphino-2′-4′-6′-triisopropylphenyl, 242 mg of tripotassium phosphate and 3 ml of dimethoxyethane was stirred at 70° C. for 3 hours. Water was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting residue was applied to a silica gel column chromatography to obtain 112 mg of 3-ethylsulfonyl-5-phenyl-N-methyl-N-(4-trifluoromethylsulfanylphenyl)picolinamide (hereinafter, referred to as Compound of Present Invention 124).

Provenance & Evidence