HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(5-Bromopyridin-3-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Reactant | 5-Bromonicotinoyl chloride | HCID 2781223 | — |
| Product | 5-(5-Bromopyridin-3-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 59758751 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 1 using N′-hydroxynicotinimidamide (Aldrich) and 5-bromonicotinoyl chloride (Alfa). 1H NMR (300 MHz, DMSO-d6) δ 8.65-8.69 (m, 1H), 8.45-8.49 (m, 1H), 8.79 (t, J=1.7 Hz, 1H), 8.84 (dd, J=1.7, 2.0 Hz, 1H), 9.07 (d, J=2 Hz, 1H), 9.28-9.29 (m, 1H), 9.34 (d, J=1.7 Hz, 1H) ppm; MS (DCl/NH3) m/z 303 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09186407B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-598b79b546a5426a8892bf05cdca71e9 |
| Source note | uspto-grants-2015_11 |