HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(Pyrazin-2-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Pyrazinecarboxylic acid | HCID 1047 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Product | 5-(Pyrazin-2-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 16418461 | — |
Reaction Steps
The titled compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and pyrazine-2-carboxylic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.66 (ddd, J=8.0, 4.9, 1.0 Hz, 1H), 8.60 (dt, J=8.0, 1.9 Hz, 1H), 8.77 (dd, J=5.0, 1.8 Hz, 1H), 8.86-8.89 (m, 1H), 8.89-8.91 (m, 1H), 9.34 (dd, J=2.4, 0.8 Hz, 1H), 9.56 (d, J=1.6 Hz, 1H) ppm; MS (DCl/NH3) m/z 226 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09186407B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-1c7554f30e2645b9b6af8c840cc3779b |
| Source note | uspto-grants-2015_11 |