HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(2,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2,5-Difluorobenzoic acid | HCID 76339 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Product | 5-(2,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 67026303 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 2,5-difluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.41-7.56 (m, 2H), 7.65 (ddd, J=7.9, 5.0, 1.0 Hz, 1H), 7.98-8.04 (m, 1H), 8.57 (dt, J=8.0, 1.9 Hz, 1H), 8.75 (dd, J=5.2, 1.6 Hz, 1H), 9.31 (dd, J=2.0, 0.8 Hz, 1H); MS (DCl/NH3) m/z 260 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09186407B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-3947b7f38528486281a99e51085f0e08 |
| Source note | uspto-grants-2015_11 |