HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminophenol → N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | Pyrimidine, 2,4-dichloro-5-methyl- | HCID 74508 | — |
| Reactant | R-112 | HCID 9904854 | — |
| Product | N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine | HCID 22061056 | — |
Reaction Steps
In a manner analogous to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloro-5-methylpyrimidine with 3-hydroxyaniline gave N2,N4-bis(3-hydroxyphenyl)-5-methyl-2,4-pyrimidinediamine. LCMS: ret. time: 16.76 min.; purity: 100%, MS (m/e): 309 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822685B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-37227fae56924516ba21181be749560e |
| Source note | uspto-grants-2014_09 |