Ammonia → HCID 6463996, compound

HRID 713781Notes

Reaction equation

HRID 713781 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15](O)=O.N>>[F:11][C:12]1[CH:13]=[C:14]([C:15]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 99683-Fluorobenzoic AcidHCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 6463996HCID 6463996, compound

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-fluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.43-7.51 (m, J=8.5, 8.5, 2.6, 1.0 Hz, 1H), 7.61-7.72 (m, 2H), 7.98 (ddd, J=9.1, 2.6, 1.4 Hz, 1H), 8.08 (ddd, J=8.0, 1.3, 1.0 Hz, 1H), 8.56 (dt, J=8.0, 1.9 Hz, 1H), 8.74 (dd, J=5.2, 1.6 Hz, 1H), 9.30 (dd, J=2.0, 0.8 Hz, 1H) ppm; MS (DCl/NH3) m/z 242 (M+H)+.

Sources & evidence

ORD record
ord-c5f475708935422ba40e604a1501edfc
Source dataset
uspto-grants-2015_11
Patent number
US09186407B2

Reaction notes

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