Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-(2,3-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| 반응물 | 2,3-difluoro-N'-hydroxybenzenecarboximidamide | HCID 3278378 | — |
| 생성물 | 3-(2,3-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 67026030 | — |
반응 단계
The title compound was prepared according to the procedure of Example 1 using 2,3-difluoro-N′-hydroxybenzimidamide (Tyger Scientific) and nicotinoyl chloride hydrochloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.42-7.61 (m, 1H), 7.67-7.85 (m, 2H), 7.91-8.04 (m, 1H), 8.57 (dt, J=8.1, 1.9 Hz, 1H), 8.92 (dd, J=4.8, 1.6 Hz, 1H), 9.36 (dd, J=2.4, 0.8 Hz, 1H) ppm; MS (DCl/NH3) m/z 260 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09186407B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-7fe2d19fd1994813be3f3485fe2f6802 |
| 출처 메모 | uspto-grants-2015_11 |