Ammonia → HCID 30028912, compound

HRID 713807Notes

Reaction equation

HRID 713807 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[Cl:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][N:20]=1)[C:15](Cl)=O.N>>[Cl:11][C:12]1[CH:13]=[C:14]([C:15]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)[CH:18]=[CH:19][N:20]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 28000032-Chloropyridine-4-carbonyl chloride

Product 1

HCID 30028912HCID 30028912, compound

Procedure

The title compound was prepared according to the procedure of Example 1 using N′-hydroxynicotinimidamide (Aldrich) and 2-chloroisonicotinoyl chloride (Maybridge). 1H NMR (300 MHz, DMSO-d6) δ 7.68 (ddd, J=7.9, 4.8, 0.8 Hz, 1H), 8.16 (dd, J=5.1, 1.4 Hz, 1H), 8.23 (dd, J=1.5, 0.8 Hz, 1H), 8.42-8.54 (m, 1H), 8.77 (dd, J=5.1, 0.7 Hz, 1H), 8.84 (dd, J=4.7, 1.7 Hz, 1H), 9.28 (dd, J=2.2, 0.8 Hz, 1H) ppm; MS (DCl/NH3) m/z 259 (M+H)+, 261 (M+H)+.

Sources & evidence

ORD record
ord-5b876e237b804befbfc275bc2cb029c6
Source dataset
uspto-grants-2015_11
Patent number
US09186407B2

Reaction notes

Loading…