Ammonia → HCID 878411, compound

HRID 713808Notes

Reaction equation

HRID 713808 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[Br:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15](Cl)=O.N>>[Br:11][C:12]1[CH:13]=[C:14]([C:15]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 74377Benzoyl chloride, 3-bromo-HCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 878411HCID 878411, compound

Procedure

The title compound was prepared according to the procedure of Example 1 using N′-hydroxynicotinimidamide (Aldrich) and 3-bromobenzoyl chloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.60-7.71 (m, 2H), 7.98 (ddd, J=8.1, 2.0, 1.0 Hz, 1H), 8.22 (ddd, J=7.4, 1.6, 1.3 Hz, 1H), 8.35 (t, J=1.8 Hz, 1H), 8.46 (dt, J=7.9, 2.0 Hz, 1H), 8.83 (dd, J=4.8, 1.6 Hz, 1H), 9.27 (dd, J=2.4, 0.8 Hz, 1H) ppm; MS (DCl/NH3) m/z 302 (M+H)+, 304 (M+H)+.

Sources & evidence

ORD record
ord-457794cfb8684cc39b7a2f56aa68891a
Source dataset
uspto-grants-2015_11
Patent number
US09186407B2

Reaction notes

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