HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → N2,N4-bis(benzyl)-5-fluoro-2,4-pyrimidinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Reactant | R-112 | HCID 9904854 | — |
| Product | N2,N4-bis(benzyl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060544 | — |
Reaction Steps
In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and benzylamine were reacted to yield N2,N4-bis(benzyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.69 (bs, 1H), 7.35-7.24 (m, 10H), 5.63 (bs, 1H), 5.27 (bs, 1H), 4.61 (d, 2H, J=6.0 Hz), 4.55 (d, 2H, J=6.0 Hz); 19F NMR (CDCl3): −48580; LCMS: ret. time: 23.73 min.; purity: 100%; MS (m/e): 309 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822685B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8d01ba469ba84516aec6e60efb63b0fa |
| Source note | uspto-grants-2014_09 |