HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxygen → 6-Bromo-2-(4-tert-butyl-cyclohexyloxy)-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxygen | HCID 977 | — |
| Reactant | HCID 178426037 | HCID 178426037 | — |
| Reactant | HCID 178515482 | HCID 178515482 | — |
| Product | 6-Bromo-2-(4-tert-butyl-cyclohexyloxy)-quinoline | HCID 66926583 | — |
Reaction Steps
Synthesized as per 6-(trans-4-tert-Butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline using 6-Bromo-quinolin-2-ol as starting material. Alkylation was confirmed to be on the oxygen by 2D NMR (HMQC) of the subsequent intermediate. ESI-MS(M+H+): 362.1/364.10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09186367B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-4f6e96e80550485da212e1efdc62e826 |
| Source note | uspto-grants-2015_11 |