HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (+)-(R)-N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | (R)-4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-amine | HCID 86679930 | — |
| Product | (+)-(R)-N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide | HCID 86699310 | 91% |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-4 [D], (+)-(R)-4-bromo-5,6,7,8-tetrahydroisoquinolin-8-amine (intermediate A-11) and acetic acid gave the title compound as off-white solid in 91% yield. MS: 269.0 (M+H+, 1Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-659cfb1312ff426a8c0b46be316416db |
| Source note | uspto-grants-2015_11 |