HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-(Trifluoromethyl)phenyl)oxazole → 4-(4-Trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-(Trifluoromethyl)phenyl)oxazole | HCID 13268414 | — |
| Reactant | 4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine | HCID 89846299 | — |
| Product | 4-(4-Trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindine | HCID 89846308 | 32% |
Reaction Steps
In analogy to the procedure described for the preparation of 4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindine (intermediate A-14 [B], batch approach), replacing 5-(3-fluoro-4-(trifluoromethyl)phenyl)-oxazole with 5-(4-trifluoromethyl-phenyl)-oxazole (CAS[87150-14-9]). The title compound was obtained as a light brown oil in 32% yield. MS: 264.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-1ce009e69cd24730a21472edc7cf6427 |
| Source note | uspto-grants-2015_11 |