HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionic Acid → (R)-N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | (R)-4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-amine | HCID 86679930 | — |
| Product | (R)-N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 86699312 | 97% |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-4 [D], (+)-(R)-4-bromo-5,6,7,8-tetrahydroisoquinolin-8-amine (intermediate A-11) and propionic acid gave the title compound as white solid in 97% yield. MS: 283.5 (M+H+, 1 Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-6b49f2d022e1499ebe215551943a201b |
| Source note | uspto-grants-2015_11 |