HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanophenylboronic acid → (rac)-4-(8-Hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Reactant | 4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-OL | HCID 71743891 | — |
| Product | (rac)-4-(8-Hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile | HCID 71811404 | 83% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-4-bromo-5,6,7,8-tetrahydroisoquinolin-8-ol (intermediate A-2) was reacted with 4-cyanophenylboronic acid to give the title compound as light brown powder in 83% yield. MS: 251.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-cb1bcf2111fb4e33bfb4df16dd7754ec |
| Source note | uspto-grants-2015_11 |