HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Fluoro-3-methylphenyl)boronic acid → (rac)-N-(4-(4-Fluoro-3-methylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Fluoro-3-methylphenyl)boronic acid | HCID 2774580 | — |
| Reactant | N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 86685953 | — |
| Product | (rac)-N-(4-(4-Fluoro-3-methylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 89846252 | 82% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide (intermediate A-1) was reacted with 4-fluoro-3-methylphenylboronic acid to give the title compound as light yellow foam in 82% yield. MS: 313.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-e4c36c3737ff4aad934591b72f4e3bb0 |
| Source note | uspto-grants-2015_11 |