HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-fluorophenylboronic Acid → HCID 71811699, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-fluorophenylboronic Acid | HCID 2778656 | — |
| Reactant | N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 86685953 | — |
| Product | HCID 71811699 | HCID 71811699 | 83% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide (intermediate A-1) was reacted with 4-chloro-3-fluorophenylboronic acid to give the title compound as light brown foam in 83% yield. MS: 333.4 (M+H+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-0d43d12749e24ad2b00df0e1d8affeb7 |
| Source note | uspto-grants-2015_11 |