HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-trifluoromethyl-phenylboronic acid → (rac)-N-(4-(3-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-trifluoromethyl-phenylboronic acid | HCID 17750050 | — |
| Reactant | N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 86685953 | — |
| Product | (rac)-N-(4-(3-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 71811698 | 80% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide (intermediate A-1) was reacted with 3-fluoro-4-(trifluoromethyl)phenylboronic acid to give the title compound as light brown foam in 80% yield. MS: 367.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b5f6a94f70324e7fa4bc821d00ccae4d |
| Source note | uspto-grants-2015_11 |