HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(trifluoromethyl)benzeneboronic acid → (rac)-N-(4-(2-Fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(trifluoromethyl)benzeneboronic acid | HCID 16414145 | — |
| Reactant | N-(4-Bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide | HCID 86685956 | — |
| Product | (rac)-N-(4-(2-Fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide | HCID 71811609 | 76% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide (intermediate A-4) was reacted with 2-fluoro-4-(trifluoromethyl)phenylboronic acid to give the title compound as grey solid in 76% yield. MS: 353.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-75f122b796654e6da7cf2773043860cd |
| Source note | uspto-grants-2015_11 |