HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-trifluoromethyl-phenylboronic acid → (rac)-N-(4-(3-Fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)ethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-trifluoromethyl-phenylboronic acid | HCID 17750050 | — |
| Reactant | N-(4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)ethanesulfonamide | HCID 89456129 | — |
| Product | (rac)-N-(4-(3-Fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)ethanesulfonamide | HCID 71811603 | 72% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (rac)-N-(4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)ethanesulfonamide (intermediate A-7) was reacted with 3-fluoro-4-(trifluoromethyl)phenylboronic acid to give the title compound as off-white solid in 72% yield. MS: 389.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-7d527efbd4a84112acabb3632c9260ed |
| Source note | uspto-grants-2015_11 |