HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(trifluoromethyl)benzeneboronic acid → (+)-(R)-4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(trifluoromethyl)benzeneboronic acid | HCID 16414145 | — |
| Reactant | (R)-4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-amine | HCID 86679930 | — |
| Product | (+)-(R)-4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-amine | HCID 71811573 | 55% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (+)-(R)-4-bromo-5,6,7,8-tetrahydroisoquinolin-8-amine (intermediate A-11) was reacted with 2-fluoro-4-(trifluoromethyl)phenylboronic acid to give the title compound as brown viscous oil in 55% yield. MS: 311.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-3e33f875f8f84f1186c4b0444f9bf4cf |
| Source note | uspto-grants-2015_11 |