HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → (+)-(R)-N-(4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (+)-(R)-4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-amine | HCID 71811573 | — |
| Product | (+)-(R)-N-(4-(2-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)methanesulfonamide | HCID 71811572 | 60% |
Reaction Steps
In analogy to the procedure described for the preparation of example 2, (+)-(R)-4-(2-fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-amine (example 74) and methanesulfonyl chloride gave the title compound as white solid in 60% yield. MS: 389.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-4cc9dd7126ef4d0d961bb96949ff9130 |
| Source note | uspto-grants-2015_11 |