HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanophenylboronic acid → (+)-(R)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Reactant | (+)-(R)-N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide | HCID 86699310 | — |
| Product | (+)-(R)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide | HCID 71811570 | 87% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (+)-(R)—N-(4-bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide (intermediate A-12) was reacted with 4-cyanophenylboronic acid to give the title compound as off-white solid in 87% yield. MS: 292.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-00d9659774b2476a9a53087c2eb6eb3c |
| Source note | uspto-grants-2015_11 |