HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-trifluoromethyl-phenylboronic acid → (+)-(R)-N-(4-(3-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-trifluoromethyl-phenylboronic acid | HCID 17750050 | — |
| Reactant | (+)-(R)-N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide | HCID 86699310 | — |
| Product | (+)-(R)-N-(4-(3-Fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide | HCID 71811568 | 83% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (+)-(R)—N-(4-bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide (intermediate A-12) was reacted with 3-fluoro-4-(trifluoromethyl)phenylboronic acid to give the title compound as light grey solid in 83% yield. MS: 353.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-a19483a100864936aefd7bf55b23767f |
| Source note | uspto-grants-2015_11 |