HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-trifluoromethyl-phenylboronic acid → 4-[3-Fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-trifluoromethyl-phenylboronic acid | HCID 17750050 | — |
| Reactant | 4-(3-Fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-[2]pyrindin-5-one | HCID 89846277 | — |
| Product | 4-[3-Fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine-7-ol | HCID 71811533 | 55% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1 (rac)-4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol (intermediate A-4 [C2]) was reacted with 3-fluoro-4-(trifluoromethyl)phenylboronic acid to give the title compound as grey solid in 55% yield. MS: 298.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-0fddc5271ab4475fa35782358049085a |
| Source note | uspto-grants-2015_11 |