HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylboronic acid → (rac)-4-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | 4-(3-Fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-[2]pyrindin-5-one | HCID 89846277 | — |
| Product | (rac)-4-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol | HCID 71811532 | 97% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1 (rac)-4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol (intermediate A-4 [C2]) was reacted with 4-(trifluoromethyl)phenylboronic acid to give the title compound as grey solid in 97% yield. MS: 280.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-07476b5cf5f34b959ed4b50201b26469 |
| Source note | uspto-grants-2015_11 |